Video Experimental Relacionado
Updated: Feb 22, 2026
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
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Reexposición a la pomalidomida después de hipotiroidismo severo relacionado con el fármaco: un reporte de caso
Francesca Bartolomei1, Tommaso Za1, Francesca Di Landro1
1Section of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.
Annals of hematology
|February 20, 2026
Resumen
La pomalidomida, utilizada para el mieloma múltiple (MM), puede causar hipotiroidismo. Se recomienda el monitoreo de la función tiroidea y la reexposición a la pomalidomida es segura después del tratamiento del hipotiroidismo.
Área de la Ciencia:
- Oncología
- Endocrinología
- Farmacología
Sus antecedentes:
- La pomalidomida es un tratamiento oral eficaz para el mieloma múltiple (MM) refractario en recaída.
- Generalmente es bien tolerado, incluso en pacientes de edad avanzada.
- El hipotiroidismo inducido por fármacos es un efecto adverso potencial.
Objetivo del estudio:
- Reportar un caso de hipotiroidismo severo inducido por pomalidomida en una paciente con mieloma múltiple.
- Evaluar la seguridad de la reexposición a la pomalidomida después del tratamiento del hipotiroidismo.
Principales métodos:
- Estudio de caso de una mujer de 71 años con MM en recaída/refractario tratada con pomalidomida.
- Monitoreo de la función tiroidea antes y durante el tratamiento.
- Inicio de terapia con levotiroxina para el hipotiroidismo.
- Reexposición a la pomalidomida después de lograr el eutiroidismo.
Principales resultados:
- La paciente desarrolló hipotiroidismo severo durante el tratamiento con pomalidomida.
- La terapia con levotiroxina resolvió rápidamente sus síntomas.
- La reexposición a la pomalidomida fue segura, sin efectos adversos sobre la función tiroidea.
Conclusiones:
- La pomalidomida puede inducir hipotiroidismo en pacientes con mieloma múltiple.
- Las pruebas regulares de la función tiroidea son cruciales durante la terapia con pomalidomida.
- La reexposición a la pomalidomida es una opción segura después de un manejo exitoso del hipotiroidismo.
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