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Inmunización oral con probióticos modificados que expresan tcdB protege a ratones contra la infección por

May M A Bahr¹, Marwa T ElRakaiby², Abd El-Nasser A Madboli³

¹Pharmaceutical and Drug Industries Research Institute, Department of Chemistry of Natural and Microbial Products, National Research Centre, 33 El Bohouth St., Dokki, P.O. Box: 12622, Cairo, Egypt.

Biologicals : journal of the International Association of Biological Standardization

|February 20, 2026

Resumen

Los probióticos genéticamente modificados administraron eficazmente una vacuna contra Clostridioides difficile, reduciendo significativamente la carga bacteriana y preservando la salud intestinal en ratones. Esta plataforma de vacuna oral viva muestra potencial para prevenir la infección por C. difficile.

Palabras clave:

Clostridioides difficile Probióticos genéticamente modificados Portadores de vacunas orales Prevención gen tcdB

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