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Updated: Feb 22, 2026
Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts
Published on: September 21, 2014
Firmas metabolómicas revelan una asociación entre patrones dietéticos saludables y envejecimiento cerebral
Lingyuan Hu1, Zhuotong Wang1, Aomiao Chen1
1Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
Objectives:
The optimal dietary pattern of brain age and related diseases remains unclear, and the relationship between dietary metabolomic signature and these conditions is still poorly understood.
Design, Setting, And Participants:
This cohort study included 13,691 participants from the UK Biobank (53.67% female, mean age 54.9 ± 7.5 years), we investigated the relationship between five healthy dietary patterns and brain age gap (BAG). Metabolomic signatures were constructed using a LASSO model, and multivariable linear regression was applied to examine the relationship between metabolomic signatures and brain age.
Results:
Higher AHEI-2010 and DASH scores were associated with reduced BAG. Specifically, higher DASH scores reduced BAG in obese populations. Metabolomic signatures accounted for 30.43% and 35.47% of the associations between dietary patterns and BAG, respectively, and were themselves significantly correlated with BAG.
Conclusion:
AHEI-2010/DASH diets and plasma metabolites are associated with brain aging, offering a metabolomic basis for personalized dietary interventions.
