Asociaciones entre la exposición a hidrocarburos aromáticos policíclicos, el estado del zinc y los perfiles lipídicos...

Abnormal lipid profiles, including changes in triglycerides, cholesterol, and phospholipids, are key concerns in healthcare due to their involvement in essential physiological processes and cellular membrane structures. Dysregulation of lipid homeostasis is associated with various clinical diseases, such as atherosclerosis, cardiovascular disease, obesity, and metabolic syndrome.

This study aimed to investigate the associations between zinc deficiency, urinary polycyclic aromatic hydrocarbon (PAH) compounds, and abnormal lipid profiles.

Data were collected from the National Health and Nutrition Examination Survey (NHANES) for the 2011-2012, 2013-2014, and 2015-2016 cycles. A weighted logit regression analysis was conducted to determine the main effect odds ratios (OR) of PAH exposure in relation to zinc deficiency and abnormal lipid profiles.

In individuals with zinc deficiency, specific PAH compounds were significantly associated with abnormal lipid profiles. Notably, 1-hydroxynaphthalene was significant in the second quantile analysis (OR: 1.503, 95 % CI: 0.983-2.298). 2-hydroxyfluorene was significant in the third tertile analysis (OR: 1.508, 95 % CI: 0.971-2.341). 1-hydroxyphenanthrene was significant in both the third tertile (OR: 1.567, 95 % CI: 1.017-2.415) and the fourth quartile (OR: 1.723, 95 % CI: 1.042-2.848) analyses.

This study identified 1-hydroxynaphthalene, 2-hydroxyfluorene, and 1-hydroxyphenanthrene as significant contributors to abnormal lipid profiles in the context of zinc deficiency. These findings highlight potential biomarkers and underscore the importance of addressing zinc deficiency to mitigate lipid-related health risks.