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Aprendizaje dirigido a objetivos en organoides corticales

Ash Robbins1, Hunter E Schweiger2, Sebastian Hernandez1

  • 1Department of Electrical and Computer Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

Cell reports
|February 20, 2026
PubMed
Resumen
Este resumen es generado por máquina.

Los organoides cerebrales demuestran aprendizaje dirigido a objetivos a través de la plasticidad neuronal impulsada por retroalimentación. El aprendizaje por refuerzo mejoró el rendimiento, pero la plasticidad requirió una transmisión glutamatérgica intacta, lo que sugiere potencial para la rehabilitación neuronal.

Palabras clave:
neurocienciainvestigación de células madreinteligencia artificialbiocomputaciónconectividad causalcontrol de circuito cerradoorganoide corticalestimulación eléctricaelectrofisiologíain vitrointeligencia de organoidesaprendizaje por refuerzo

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