Video Experimental Relacionado
Updated: Feb 22, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Transiciones de síntomas longitudinales predicen el riesgo de tuberculosis incidente en la búsqueda activa de casos
Esther Jung1, José Victor Bortolotto Bampi2, Alessandra Moura da Silva2
1Stanford University School of Medicine, Stanford, California, United States.
Abstract:
Tuberculosis (TB) screening often relies on cross-sectional symptom assessment. To determine the added value of longitudinal symptom monitoring, we conducted a prospective cohort study among 2,282 incarcerated men in Brazil. Every four months, participants were assessed for symptoms and incident TB (Xpert or culture positive). Compared to remaining asymptomatic, developing symptoms was associated with higher TB risk (aRR 2.31; 95% CI 1.55-3.43), strongest among those with prior radiographic abnormalities (aRR 2.49; 95% CI 1.56-3.97), while remaining symptomatic was not associated (aRR 1.27; 95% CI 0.72-2.24). Longitudinal symptom monitoring may enhance TB screening in high-risk settings, particularly in complement with radiography.
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