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Updated: Feb 22, 2026

Author Spotlight: Unlocking the World of Intrinsically Disordered Regions with Cellular Sensing and Responses
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PERK retiene un estado predominantemente monomérico en condiciones de estrés del RE

Konstantina Georgoula1, Luo Liu2, Simone Jung3

  • 1Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Max Rubner Center for Cardiovascular Metabolic Renal Research (MRC), United States of America; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin,Germany; School of Physics and Astronomy, University of St Andrews, KY16 9AJ St Andrews, UK; Charité-Universitätsmedizin Berlin, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.

Journal of molecular and cellular cardiology
|February 20, 2026
PubMed
Resumen

La vía de respuesta a proteínas desplegadas (UPR) implica el ensamblaje de la quinasa del RE similar a PKR (PERK). Este estudio revela que la oligomerización de PERK ocurre independientemente del estrés del RE, desafiando los modelos actuales de activación de la UPR.

Palabras clave:
CardiomiocitosBrillo molecularOligomerizaciónPERKRespuesta a proteínas desplegadas

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