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Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Actualizaciones en linfomas de la zona marginal

Marie Donzel¹, Lucile Baseggio², Camille Laurent³

¹Institut de pathologie multisite, hospices civils de Lyon, Lyon, France; Université Claude-Bernard Lyon 1, 69100 Villeurbanne, France; Centre international de recherche en infectiologie (CIRI), Institut national de la santé et de la recherche médicale (Inserm) U1111, Centre national de la recherche scientifique (CNRS), UMR5308, École normale supérieure de Lyon, Lyon, France.

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|February 20, 2026

Resumen

Esta revisión cubre cinco subtipos de linfoma de la zona marginal (MZL), incluidas las formas pediátricas y cutáneas recién definidas. Destaca características compartidas y distintas, centrándose en datos moleculares para mejorar el diagnóstico.

Palabras clave:

linfoma de la zona marginal extraganglionar linfoma de células B indolente linfoma de células B indolente linfoma de la zona marginal linfoma de la zona marginal extraganglionar linfoma primario cutáneo de la zona marginal linfoma esplénico de la zona marginal proliferación linfoproliferativa linfoproliferación MALT linfoma de la zona marginal linfoma primario cutáneo de la zona marginal linfoma esplénico de la zona marginal

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Área de la Ciencia:

Hematología
Oncología
Patología

Sus antecedentes:

Las clasificaciones de la OMS y la ICC de 2022 delinean cinco entidades de linfoma de la zona marginal (MZL).
Estas incluyen MZL extraganglionar (linfoma MALT), MZL nodal (NMZL), MZL esplénico (SMZL), MZL nodal pediátrico (PNMZL) y MZL cutáneo primario (PC-MZL).
Si bien comparten características comunes, cada subtipo de MZL exhibe características únicas.

Objetivo del estudio:

Revisar las entidades recién definidas de linfoma de la zona marginal nodal pediátrica (PNMZL) y linfoma de la zona marginal cutáneo primario (PC-MZL).
Discutir datos moleculares recientes relevantes para el diagnóstico de linfomas de la zona marginal.
Proporcionar una visión general actualizada de los subtipos de MZL reconocidos.

Principales métodos:

Revisión de literatura de clasificaciones recientes y estudios moleculares.
Análisis comparativo de características morfológicas, inmunofenotípicas y genéticas en subtipos de MZL.
Enfoque en entidades novedosas y avances diagnósticos.

Principales resultados:

Cinco entidades distintas de MZL son reconocidas, con PNMZL y PC-MZL siendo delineadas recientemente.
Existen características compartidas y distintas entre los subtipos de MZL, lo que impacta el diagnóstico.
Los datos moleculares emergentes ofrecen potencial para mejorar la precisión diagnóstica.

Conclusiones:

La clasificación precisa de los subtipos de MZL es crucial para el manejo adecuado del paciente.
La investigación adicional sobre características moleculares mejorará la precisión diagnóstica.
La revisión enfatiza la importancia de las clasificaciones actualizadas y las herramientas diagnósticas para MZL.