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Variaciones mecánicas y microestructurales regionales en los aneurismas aórticos torácicos ascendentes influenciados

Omid Ghorbani¹, Robert Matongo Persson², Mohammad Javad Sadeghinia¹

¹Department of Structural Engineering, Norwegian University of Science and Technology, Trondheim, Norway.

Acta biomaterialia

|February 21, 2026

Resumen

Los aneurismas aórticos torácicos ascendentes (ATAA) muestran variadas propiedades mecánicas debido a las diferencias regionales. Los pacientes con válvula aórtica bicúspide (VAB) exhiben rigidez y alineación de colágeno únicos, lo que afecta la evaluación del riesgo.

Área de la Ciencia:

Ingeniería Biomédica Ingeniería Biomédica.
Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
Ciencia de los materiales Ciencia de los materiales.

Sus antecedentes:

Los aneurismas aórticos torácicos ascendentes (ATAA) muestran una heterogeneidad biomecánica regional.
Los cambios microestructurales y las comorbilidades influyen en las propiedades de ATAA.
Comprender estas variaciones es crucial para la estratificación del riesgo.

Objetivo del estudio:

Investigar las variaciones regionales en la microestructura y las propiedades mecánicas de la pared ATAA.
Desarrollar un modelo constitutivo motivado por la microestructura para el tejido ATAA.
Correlacione el comportamiento mecánico con el fenotipo de la válvula aórtica y los factores del paciente.

Principales métodos:

Se recolectaron muestras de pared ATAA de 10 pacientes después de la reparación.
Realizó pruebas de tracción biaxial plana y microscopía de dos fotones.
Parámetros de material determinados para un modelo constitutivo que incorpora microestructura.

Principales resultados:

Se observaron diferencias significativas entre y dentro de los pacientes en las propiedades mecánicas.
Los pacientes con válvula aórtica bicúspide (VAB) mostraron una rigidez regional distinta y una distribución de fibra de colágeno.
El grosor de la pared, el fenotipo de la válvula aórtica, la hipertensión y la edad influyeron en la rigidez del tejido.

Conclusiones:

Las variaciones regionales y los cambios microestructurales son críticos para la estratificación del riesgo ATAA.
Un modelo motivado por la microestructura predice con precisión el comportamiento de los tejidos.
Los modelos computacionales específicos del paciente son esenciales para la gestión de ATAA.

Palabras clave:

El aneurisma es un aneurisma.Ascensión de la aorta torácica ascendente.La válvula aórtica bicúspide es una válvula Colágeno y elastina.Las microestructuras son microestructuras.Microscopía multifotónica de muchos fotones.Prueba de resistencia a la tracción planar biaxial.Modelado de tejidos.La válvula aórtica tricúspide es una válvula

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