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La versatilidad de la coordinación y la bioactividad mejorada de los complejos Co2+, Cu2+ y Cd2+ derivados de la base
Abrar K Elshewemy1, Esam A Gomaa1, Hamed M Abou El Nadar1
1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
BMC chemistry
|February 21, 2026
Resumen
Se sintetizó y caracterizó un nuevo ligando de base de Schiff y sus complejos de cobalto, cobre y cadmio. Estos compuestos muestran actividades antibacterianas, antifúngicas, antioxidantes, de unión al ADN y anticancerígenas prometedoras.
Área de la Ciencia:
- Coordinación Química de la Coordinación
- Ciencia de los materiales Ciencia de los materiales.
- Química Medicinal Química medicinal es el campo de la Química Medicinal.
Sus antecedentes:
- Las bases de Schiff son ligandos versátiles en la química de la coordinación.
- Los complejos metálicos a menudo exhiben actividades biológicas mejoradas en comparación con los ligandos libres.
Objetivo del estudio:
- Sintetice y caracterice un nuevo ligando de base de Schiff y sus complejos Co (II), Cu (II) y Cd (II).
- Investigar las propiedades estructurales, espectrales, electroquímicas y biológicas de los compuestos sintetizados.
Principales métodos:
- Reacción de condensación para la síntesis de bases de Schiff.
- Complejamiento con iones metálicos.
- Los análisis espectroscópicos (FT-IR, UV-Vis, RMN, ESR) y microscópicos (PXRD, TEM) también se utilizan.
- Análisis físico-químicos (CHN, conductividad, térmico). análisis físico-químicos (CHN, conductividad, térmico).
- Cálculos de la Teoría Funcional de la Densidad (DFT).
- Voltametría cíclica.
- Ensayos biológicos (antibacteriano, antifúngico, antioxidante, unión al ADN, citotoxicidad).
Principales resultados:
- Se determinaron geometrías planas cuadradas octaédricas mononucleares y dinucleares para los complejos.
- Los estudios de DFT apoyaron las tendencias experimentales de espectro y reactividad.
- El análisis electroquímico reveló comportamientos cuasi-reversibles/irreversibles.
- La base Schiff y sus complejos metálicos demostraron significativas actividades antibacterianas, antifúngicas, antioxidantes, de unión al ADN y citotóxicas in vitro contra las líneas celulares HepG2 y MCF-7.
Conclusiones:
- El ligando base de Schiff sintetizado y sus complejos metálicos poseen diversos modos de coordinación y exhiben actividades biológicas prometedoras.
- Estos hallazgos resaltan el potencial de estos compuestos como agentes terapéuticos y en aplicaciones de la ciencia de los materiales.
Palabras clave:
Las actividades biológicas son actividades biológicas.Voltametría cíclica La voltametría cíclica es la voltametría cíclica.Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano Gaussiano GaussianoLa piridina es un dicarbohidrato de piridina.La base de navegación es la base de navegación.Más Videos Relacionados
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