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Los cambios causados por el envejecimiento de la microbiota intestinal impulsan la disfunción de la barrera

Huoyan Liang¹, Xianfei Ding¹, Shaohua Liu¹

¹Department of Critical Care Medicine, Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center, Zhengzhou, People's Republic of China.

|February 21, 2026

Resumen

El envejecimiento agrava la sepsis al aumentar los aerógenos de Klebsiella, que produce histamina (HA). Esta histamina perjudica la función de la barrera intestinal al interrumpir la vía Nlrp6-LC3, lo que sugiere que el eje HA-Nlrp6-LC3 es un objetivo terapéutico para la sepsis en adultos mayores.

Área de la Ciencia:

Microbiología Microbiología.
Inmunología Inmunología.
Gastroenterología y Gastroenterología.

Sus antecedentes:

El envejecimiento está relacionado con peores resultados de sepsis debido a mecanismos inflamatorios poco conocidos.
El papel de la microbiota intestinal en la exacerbación de la sepsis relacionada con la edad requiere más investigación.

Objetivo del estudio:

Para aclarar los mecanismos por los cuales el envejecimiento impacta la microbiota intestinal y exacerba la sepsis.
Identificar factores microbianos y metabólicos específicos que contribuyen al aumento de la inflamación en pacientes con sepsis de edad avanzada y en ratones.

Principales métodos:

Trasplante de microbiota fecal de ratones viejos a ratones jóvenes.
Secuenciación de 16S rDNA, metabolomía y análisis histopatológico.
Experimentos in vivo e in vitro con bacterias genéticamente modificadas.

Principales resultados:

Aumento de la abundancia de Klebsiella aerogenes (K. aero) en huéspedes sépticos envejecidos.
K. aero eleva la producción de histamina (HA), lo que lleva a una disfunción de la barrera intestinal.
El HA inhibió la expresión de Nlrp6 y la unión a LC3, deteriorando la autofagia y empeorando la inflamación.

Conclusiones:

La histamina derivada de Klebsiella aerogenes agrava la sepsis a través del eje HA-Nlrp6-LC3.
Dirigirse a este eje ofrece una estrategia terapéutica potencial para la sepsis, especialmente en personas mayores.

Palabras clave:

K. Aero Aero Aero Aero Aero K. Aero Aero Aero La sepsis es una sepsis.El envejecimiento del envejecimiento.La histamina es una histamina.Disfunción de la barrera intestinal disfunción de la barrera intestinal.

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