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Membrana fibrosa electrospun con triples efectos sinérgicos para la terapia del cáncer

Xia Li¹, Congyan Wu², Jielong Luo²

¹State Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing, 400715, China; Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing, 400715, China; College of Textile and Apparel Engineering, Xin Jiang Institute of Light Industry Technology, Xinjiang, 830021, China.

Biomaterials advances

|February 22, 2026

Resumen

Este estudio desarrolló una nueva membrana fibrosa de triple terapia utilizando fibroína de seda (SF), poli (ácido láctico-co-glucólico) (PLGA), verde indocianina (ICG) y clorhidrato de doxorubicina (DOX) para mejorar el tratamiento del cáncer. La membrana exhibe efectos fototérmicos, fotodinámicos y de quimioterapia, inhibiendo significativamente el crecimiento del tumor.

Área de la Ciencia:

Ciencia de los Biomateriales Ciencia de los Biomateriales.
Nanotecnología La nanotecnología es la nanotecnología.
Terapia del cáncer Terapia del cáncer.

Sus antecedentes:

La complejidad del tumor requiere terapias combinadas para mejorar la eficacia.
Los tratamientos actuales de una sola modalidad se enfrentan a limitaciones para abordar la heterogeneidad tumoral.

Objetivo del estudio:

Desarrollar una membrana fibrosa multifuncional para la triple terapia sinérgica contra el cáncer.
Para investigar los efectos combinados fototérmicos, fotodinámicos y de quimioterapia del material desarrollado.

Principales métodos:

El electrospinado de fibroína de seda (SF), poli (ácido láctico-co-glicólico) (PLGA), verde indocianina (ICG) y clorhidrato de doxorubicina (DOX) para crear una membrana fibrosa.
Evaluación de las propiedades fototérmicas, generación de especies reactivas de oxígeno (ROS) y cinética de liberación de fármacos.
Evaluación in vitro de la citotoxicidad contra las células HepG2 y B16.
Estudios in vivo para evaluar la inhibición del crecimiento tumoral.

Principales resultados:

La membrana SF / PLGA / ICG / DOX demostró una conversión fototérmica significativa, aumentando la temperatura en 43.9 ° C en 20 minutos bajo irradiación de infrarrojo cercano (NIR).
La irradiación NIR indujo la generación de ROS y la liberación controlada de clorhidrato de doxorubicina (DOX), lo que condujo a una apoptosis efectiva de las células tumorales.
La triple terapia sinérgica inhibió significativamente el crecimiento tumoral in vivo y erradicó las células HepG2 y B16 in vitro.

Conclusiones:

La membrana electrospun SF/PLGA/ICG/DOX ofrece una estrategia prometedora para la terapia de cáncer localizado mediante la combinación de fototérmica, fotodinámica y quimioterapia.
Este material multifuncional demuestra un potencial significativo para mejorar los resultados terapéuticos en el tratamiento del cáncer.

Palabras clave:

Terapia de tratamiento del cáncer.La quimioterapia es una quimioterapia.Liberación controlada de la liberación.El electrospinado es un proceso de electrospinado.El efecto fotodinámico es un efecto fotodinámico.La terapia fototérmica es una terapia fototérmica.

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