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Disfunción circadiana en el delirio: una revisión sistemática.

J Reid Black1, Rachel E Landrum2, Emma O'Hagan3

  • 1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States of America.

Journal of the Academy of Consultation-Liaison Psychiatry
|February 22, 2026
PubMed
Resumen

El delirio está relacionado con la disfunción circadiana, pero la conexión es compleja. La terapia de luz brillante se muestra prometedora para la prevención, mientras que otras intervenciones tienen resultados inconsistentes, lo que requiere más investigación.

Palabras clave:
La disfunción circadiana es una disfunción circadiana.Ritmos circadianos Los ritmos circadianos son los ritmos circadianos de las personas.consulta-enlace psiquiatría psiquiatríaEl delirio delirio delirio.Ciclo de sueño-vigilia Ciclo de sueño-vigiliaLa revisión sistemática es una revisión sistemática.

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Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • Medicina del sueño Medicina del sueño.
  • Geriatría La geriatría es la especialidad de la geriatría.

Sus antecedentes:

  • El delirio es un síndrome neuropsiquiátrico común con una morbilidad significativa.
  • La interrupción circadiana es cada vez más reconocida como una característica central del delirio.
  • La relación precisa entre la disfunción circadiana y el delirio está poco explorada.

Objetivo del estudio:

  • Revisar sistemáticamente la relación entre la disfunción circadiana y el delirio.
  • Para identificar las métricas de las perturbaciones circadianas en el delirio.
  • Para evaluar las intervenciones y las variables ambientales que influyen en el curso del delirio.

Principales métodos:

  • Revisión sistemática siguiendo las directrices de PRISMA.
  • Buscado PubMed, Embase, PsycINFO, Web of Science hasta octubre de 2024.
  • Se incluyen estudios en humanos en inglés; datos cualitativos sintetizados.

Principales resultados:

  • 58 de 1908 artículos cumplieron con los criterios de inclusión.
  • La actigrafía, la polisomnografía y el EEG detectaron diferencias entre el sueño y el ritmo circadiano en el delirio.
  • La terapia de luz brillante es prometedora para la prevención del delirio; los agentes melatonérgicos fueron inconsistentes.

Conclusiones:

  • La asociación entre el delirio y la disfunción circadiana es compleja y no se comprende completamente.
  • Biomarcadores fisiológicos como la melatonina y el cortisol mostraron vínculos inconsistentes con el delirio.
  • Se necesitan estudios más grandes y rigurosos con medidas multimodales para guiar las estrategias.