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Updated: Feb 24, 2026

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Síntesis de β-cetoamidas compatible con ADN como intermedios para la diversificación química en ADN

Xianfeng Li^1,2, Zehao Yin², Qiuyi Chen²

¹Pharmaceutical Department, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing 404100, China.

Organic letters

|February 23, 2026

Abstract:

The β-ketoamide motif represents both a privileged scaffold and a versatile synthetic intermediate in medicinal chemistry. Herein, we developed a DNA-compatible method for the efficient conversion of various DNA-conjugated amines into β-ketoamides. The resulting β-ketoamides facilitate rapid diversification into a panel of structurally diverse molecular scaffolds. Importantly, the synthetic route and subsequent derivatization steps were validated to be fully compatible with DNA encoding, offering a reliable and versatile platform for DNA-encoded library synthesis.

Palabras clave:

química medicinal química sintética biotecnología bibliotecas codificadas con ADN descubrimiento de fármacos síntesis de β-cetoamidas

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