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Videos de Conceptos Relacionados

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Metabolism of Chemolithotrophs01:15

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Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
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Overview of Metabolism01:40

Overview of Metabolism

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
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¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons01:03

¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons

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Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
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Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

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The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
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¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

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Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
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An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
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Aprendizaje desde Todas las Vistas: Un Marco Contrastivo Multivista para la Anotación de Metábolitos

Yan Zhou Chen1, Soha Hassoun1,2

  • 1Department of Computer Science, Tufts University, Medford, Massachusetts 02155, United States.

Analytical chemistry
|February 23, 2026
PubMed
Resumen

Un nuevo marco, Proyección Multivista (MVP), mejora la identificación de metabolitos en metabolómica al analizar conjuntamente datos moleculares y espectrales. Este enfoque mejora la precisión de la anotación espectral, avanzando en la investigación de enfermedades y el descubrimiento de fármacos.

Sus antecedentes:

Palabras clave:
metabolómicaanotación espectralaprendizaje automáticoaprendizaje contrastivoproyección multivistadescubrimiento de fármacosquímica computacionalbioinformática

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  • La metabolómica, que utiliza espectrometría de masas de alto rendimiento, es crucial para comprender la bioquímica celular, los mecanismos de las enfermedades, el desarrollo de fármacos y la medicina personalizada.
  • Las bajas tasas de anotación espectral debido al desafío de asignar estructuras moleculares a espectros medidos obstaculizan los avances en metabolómica.

Conclusiones:

  • MVP proporciona una base flexible y extensible para aprender de múltiples vistas de datos de moléculas/espectros.
  • El marco demuestra un rendimiento superior o comparable a los métodos existentes para la anotación espectral.
  • Las tasas de anotación mejoradas facilitadas por MVP pueden acelerar los descubrimientos en campos relacionados con la metabolómica.