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Updated: Feb 24, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
Disritmia por sobredosis de verapamilo en una mujer joven
Abdollah Malakian1, Ensiyeh Taghizadeh1, Zakaria Zakariaei2
1Department of Emergency Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, mazums.ac.ir.
Abstract:
Verapamil (VER) is characterized as a calcium channel blocker (CCB) that can be intentionally or unintentionally overdosed. This drug, like other CCBs, inhibits the entry of calcium into vascular and myocardial tissues through L-type channels. VER exerts negative inotropic and chronotropic effects on the myocardium through antagonistic L-type calcium channels, and an overdose of this drug can result in a decrease in cardiac output, hypotension, and shock. In this report, we describe a unique case of VER toxicity in a 30-year-old woman who experienced a dysrhythmia and heart block after intentionally ingesting 800 mg of sustained-release VER tablets.
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