Catálogo del Modelo PRECISE TBI: Aumentando la Accesibilidad y la Reproducibilidad en la Investigación de TBI

Preclinical traumatic brain injury (TBI) research relies on experimental models that vary by mechanism, parameters, surgical procedures, species, strains, and ages, to name a few. While these models are crucial for understanding injury mechanisms and testing therapies, the progress in translating this knowledge to the clinic has been limited. This is in part due to fragmented resources and inconsistent reporting of critical variables. Here, we introduce the PRECISE-TBI model catalog, a centralized, queryable resource that consolidates metadata from published studies. The catalog integrates curated annotations from more than 450 papers, including details such as age, sex, strain, model type, device, and injury parameters. Where available, entries are also linked to protocols and datasets to enhance transparency and reproducibility. The Model Catalog serves as a living resource that enables cross-study comparison, identifies gaps in reporting, and connects the literature to datasets, protocols, device information, and other relevant resources. Analysis of the initial catalog entries revealed gaps in the reporting of device, age, and weight. In contrast, the reporting of sex improved over time, with over 90% of recent studies within the catalog papers reporting sex. Strain was also reported in most studies, with consistent reporting of specificity, especially for the C57 mice substrain. We expect the Model Catalog to serve as a valuable tool to enhance study design and reproducibility in preclinical TBI research while advancing FAIR data principles in the TBI field.