Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Regulation of Metabolism01:19

Regulation of Metabolism

11.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.8K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

1.4K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.4K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

1.0K
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
1.0K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

3.0K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.0K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.6K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.6K
Metabolic Rate01:25

Metabolic Rate

1.3K
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
1.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

GLP-1 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study.

Diabetes, obesity & metabolism·2026
Same author

RNA helicase associated with AU-rich elements (RHAU) regulates hepatic glucose homeostasis via a novel microRNA-150-Notch3-peroxisome proliferator-activated receptor γ pathway.

International journal of biological macromolecules·2026
Same author

Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity.

Nature·2026
Same author

Hypocalcemia in Dialysis Is Not Associated with Increased Mortality: Evidence from a Population-Based Cohort.

Nutrients·2026
Same author

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin-1 to Restore Vascular Homeostasis After Ischemic Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Whole-Embryo 3D Quantification Reveals Conserved Topological Design and Scaling of Germ Layers in Xenopus.

bioRxiv : the preprint server for biology·2026
Same journal

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

bioRxiv : the preprint server for biology·2026
Same journal

M1C IS NECESSARY FOR DARAXONRASIB RESISTANCE OF NSCLC KRAS(G12C) MUTANT CELLS.

bioRxiv : the preprint server for biology·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Feb 24, 2026

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
10:45

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

Published on: December 19, 2012

20.8K

Un circuito neuronal preóptico que modula la flexibilidad metabólica

Julian M Roessler, Matthew Alkire, Nathan Nigrin

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    Resumen
    Este resumen es generado por máquina.

    El cerebro

    Palabras clave:
    neurocienciametabolismoflexibilidad metabólicaneuronasmúsculo esqueléticoglucosaácidos grasossistema nervioso centralendocrinología

    Más Videos Relacionados

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
    08:36

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

    Published on: June 7, 2024

    725
    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
    11:45

    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

    Published on: November 14, 2013

    12.7K

    Videos de Experimentos Relacionados

    Last Updated: Feb 24, 2026

    Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
    10:45

    Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

    Published on: December 19, 2012

    20.8K
    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
    08:36

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

    Published on: June 7, 2024

    725
    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
    11:45

    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

    Published on: November 14, 2013

    12.7K

    Área de la Ciencia:

    • Neurociencia
    • Metabolismo
    • Endocrinología

    Sus antecedentes:

    • La flexibilidad metabólica es crucial para la supervivencia, ya que permite a los animales adaptar el uso de combustible a los cambios ambientales.
    • Si bien las hormonas regulan la flexibilidad metabólica, el papel del sistema nervioso central se comprende menos.
    • El área preóptica anteroventral (POA ventral) contiene neuronas involucradas en el torpor y la regulación metabólica.

    Objetivo del estudio:

    • Investigar cómo la activación de neuronas específicas en el POA ventral influye en la selección y utilización del combustible metabólico.
    • Identificar los mecanismos por los cuales estas neuronas controlan el metabolismo de la glucosa y los ácidos grasos en tejidos periféricos.
    • Explorar el papel del sistema nervioso central en la coordinación de la flexibilidad metabólica de todo el cuerpo.

    Principales métodos:

    • Activación aguda de neuronas glutamatérgicas Adcyap1+ que regulan el torpor (Vglut2/PACAP del POA ventral) en ratones.
    • Medición de la utilización de combustible de todo el cuerpo (glucosa frente a ácidos grasos).
    • Evaluación de la tolerancia a la glucosa y la sensibilidad a la insulina en el músculo esquelético.
    • Investigación del papel de la corticosterona en la mediación de los cambios metabólicos.

    Principales resultados:

    • La activación de las neuronas Vglut2/PACAP del POA ventral activado cambió rápidamente el uso de combustible de glucosa a ácidos grasos.
    • Este cambio se asoció con una reducción de la utilización de glucosa y una resistencia selectiva a la insulina en el músculo esquelético.
    • La reprogramación metabólica fue mediada en parte por la corticosterona, independientemente de la inervación muscular directa.
    • El silenciamiento de estas neuronas mejoró la tolerancia a la glucosa, lo que indica un control bidireccional.

    Conclusiones:

    • Una nueva vía neural desde el POA ventral hasta el músculo esquelético regula dinámicamente la utilización de glucosa y la flexibilidad metabólica.
    • El sistema nervioso central desempeña un papel crítico en la coordinación de la selección de combustible y la adaptación metabólica.
    • La focalización de esta vía podría ofrecer nuevas estrategias para el manejo de enfermedades metabólicas.