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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

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Published on: January 22, 2013

Alta expresión de la proteína PVR marca el carcinoma de células renales de tipo claro con diseminación metastásica

Paola Kučan Brlić¹, Ema Bellulovich¹, Mijo Golemac¹

¹Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Frontiers in immunology

|February 23, 2026

Resumen

La expresión tisular del receptor de poliovirus (PVR), no los niveles séricos, muestra potencial como marcador pronóstico en el carcinoma de células renales, particularmente en subtipos de células claras, relacionando el PVR alto con la progresión metastásica y la reducción de la supervivencia.

Área de la Ciencia:

Oncology; Immunology; Biomarker Discovery

Sus antecedentes:

Poliovirus receptor (PVR) is an emerging therapeutic target for cancer treatment.; Its prognostic and predictive value in renal and bladder cancers is largely unexplored.; PVR is broadly expressed across various malignancies.

Objetivo del estudio:

To investigate the prognostic and predictive value of PVR expression in renal and bladder cancers.; To analyze both total PVR and its secreted isoform in tumor tissue and serum.; To correlate PVR expression with clinical outcomes and tumor characteristics.

Principales métodos:

Quantitative immunohistochemical analysis of PVR in tumor tissues (bladder, renal cell carcinoma - clear cell and papillary subtypes).; Enzyme-linked immunosorbent assay (ELISA) for total circulating PVR in matched serum samples.; Development of an isoform-specific assay for secreted PVR.

Principales resultados:

Elevated serum PVR in bladder and renal cancer patients, but no correlation with tissue PVR.; In bladder cancer, tissue PVR correlated with tumor grade and lymphovascular invasion.; In renal cancer, PVR expression was subtype-dependent; high PVR linked to reduced survival and metastasis in clear cell carcinoma.

Conclusiones:

PVR tissue expression, particularly in clear cell renal cell carcinoma, may serve as a prognostic marker.; High PVR expression is associated with metastatic progression in clear cell renal cell carcinoma.; PVR warrants further investigation as a biomarker and therapeutic target in renal cancers.

Palabras clave:

PVR cáncer de vejiga metástasis marcador pronóstico carcinoma de células renales

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