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Updated: Feb 24, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Published on: January 12, 2024

Descubrimiento de la eficiencia específica de BCL-xL de PROTAC y las vías de disociación utilizando espectrometría de

Mohamed I Gadallah^1,2, Kailyn L Nonhof¹, Digant Nayak³

¹Department of Chemistry, The University of Texas at Austin Austin TX 78712 USA jbrodbelt@cm.utexas.edu.

Chemical science

|February 23, 2026

Resumen

Este estudio utiliza la espectrometría de masas nativa (MS) para cribar y caracterizar rápidamente los quimeras dirigidas a la proteólisis (PROTAC) que degradan la proteína antiapoptótica BCL-xL. MS nativa analiza eficazmente los PROTAC, revelando información sobre la formación y estabilidad del complejo ternario para el desarrollo de terapias contra el cáncer.

Palabras clave:

espectrometría de masas nativa PROTAC BCL-xL complejo ternario química medicinal descubrimiento de fármacos biología química ingeniería de proteínas diseño de fármacos terapia contra el cáncer

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