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Updated: Feb 24, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

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Nefropatía de Membrana Anti-Receptor de Fosfolipasa A2 que se Presenta como Quejas Geriátricas Comunes: Un Informe de

Wai Tak Victor Li¹, Kwan Hung Wu¹, Oi Yee Lin²

¹Department of Medicine, Queen Mary Hospital, Hong Kong, HKG.

|February 23, 2026

Abstract:

Anti-phospholipase A2 receptor (anti-PLA2R) antibodies are an established cause of primary membranous nephropathy (MN). However, typical symptoms of proteinuria, such as peripheral oedema and frothy urine, are not easily identified in the elderly, and other non-specific presentations, such as hypoglycaemia and fluid overload, may lead to delays in diagnosis. We report a case of anti-PLA2R-associated MN in an elderly woman who presented with fluid overload and recurrent hypoglycaemia, both of which are common in this age group. Renal function and anti-PLA2R antibody titres improved substantially following treatment with rituximab. This case underscores the importance of early clinical suspicion and timely intervention in elderly patients in order to preserve residual renal function and optimise outcomes.

Palabras clave:

anticuerpos anti-receptor de fosfolipasa A2 enfermedad renal crónica fragilidad nefropatía primaria de membrana rituximab

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