Video Experimental Relacionado

Updated: Feb 24, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

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Published on: November 9, 2019

Inducción Asimétrica con Donantes Quirales de Enlace Carbono

Yuanling Pang¹, Xinxin Li¹, Hang Zhou¹

¹School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.

Chemistry (Weinheim an der Bergstrasse, Germany)

|February 23, 2026

Abstract:

Carbon bonding has recently been introduced as a new tool in organic synthesis. Yet, it remains unclear whether this unique weak interaction can induce chirality or not. Herein, we report the synthesis of chiral carbon-bonding donors, and present the proof-of-concept study on asymmetric induction using this noncovalent force. Employing the oxa-Pictet-Spengler reaction as a benchmark, the experimental results demonstrate that chiral carbon-bonding donors can exert asymmetric induction over oxocarbenium ion intermediates. While the enantioselectivity in such a very first attempt is modest, it unequivocally validates carbon bonding as a feasible method for asymmetric induction, paving the way for its future development in more efficient asymmetric synthesis.

Palabras clave:

inducción asimétrica esqueleto de barbitúrico enlace carbono quiral interacción no covalente

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