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755-nm Picosecond vs. Nanosecond Alexandrite Lasers for Tattoo Removal: A Randomized, Split-Tattoo Clinical Trial
Gang Ma1,2, Yue Han1, Linting Huang1
1Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Plastic and reconstructive surgery
|February 23, 2026
Resumen
The 755-nm picosecond alexandrite laser (PSAL) offers superior tattoo removal compared to the nanosecond alexandrite laser (NSAL). PSAL demonstrated higher clearance rates and reduced adverse events, making it a more effective option for tattoo removal.
Área de la Ciencia:
- Dermatology
- Aesthetic Medicine
- Laser Technology
Sus antecedentes:
- Picosecond laser technology presents theoretical advantages for tattoo removal over traditional nanosecond lasers.
- Limited high-level clinical evidence exists comparing 755-nm alexandrite picosecond and nanosecond lasers for tattoo removal.
Objetivo del estudio:
- To compare the efficacy and safety of 755-nm picosecond alexandrite laser (PSAL) versus nanosecond alexandrite laser (NSAL) for tattoo removal.
- To evaluate clearance scores, satisfactory clearance rates, pain, and adverse events associated with each laser modality.
Principales métodos:
- A prospective, randomized, split-tattoo trial involving 30 subjects with black/blue tattoos.
- Tattoos were treated with either PSAL or NSAL over five sessions at 3-month intervals, followed by a 6-month follow-up.
- Outcomes measured included visual analogue scale (VAS) clearance scores, satisfactory clearance (VAS ≥7), pain, and adverse events.
Principales resultados:
- PSAL achieved significantly higher clearance scores (8 vs. 5; p < 0.0001) and satisfactory clearance rates (73.3% vs. 23.3%; p = 0.0003) compared to NSAL.
- Complete clearance was observed in 10% of PSAL-treated sites versus none with NSAL.
- PSAL showed reduced acute complications (bleeding, blistering, crusting) but a higher incidence of hyperpigmentation (21.33% vs. 12%).
Conclusiones:
- The 755-nm PSAL significantly outperforms NSAL in tattoo removal efficacy.
- Further optimization of PSAL parameters may enhance outcomes and minimize pigmentary issues.
- PSAL represents an advanced and effective option for tattoo removal, particularly for black/blue inks.
