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Updated: Feb 25, 2026

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Ensamblaje del esqueleto de 8-tia-2-aza-1-fosfabiciclo[3.2.1]oct-3-eno a partir de fosfuranuro, azufre e iminas

Chenyong Xu¹, Siyu Yuan¹, Rongqiang Tian¹

¹College of Chemistry, International Phosphorus Laboratory, Zhengzhou University, Zhengzhou 450001, P. R. China.

The Journal of organic chemistry

|February 23, 2026

Abstract:

The demand for the efficient assembly of structurally complex molecules from simple starting materials continues to grow alongside advances in organic synthesis. Here, we utilize the ring strain of phosphiranes to construct an 8-thia-2-aza-1-phosphabicyclo[3.2.1]oct-3-ene skeleton via a tandem reaction of phosphiranide, sulfur, and alkynyl imines. The proposed mechanism involves intramolecular attack by in situ generated allenamine anion on the phosphirane, leading to a C-P bond cleavage and formation of a strained cyclic allene intermediate, which furnishes the bicyclic products.

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