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Actualizaciones en medicina clínica: MASLD en niños y adolescentes

Sander Lefere¹, Bart G P Koot², Jake P Mann³

¹Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium.

Journal of hepatology

|February 23, 2026

Abstract:

Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly common liver disease, with a global prevalence estimated up to 7.5% and substantial concern for hepatic and extrahepatic complications even in early life. In this paper, we review recent advances in epidemiology, genetics, early-life risk factors, natural history and comorbidities, focusing on emerging data published in the last 3 years. We also outline a practical approach to the management of MASLD in children, integrating newly developed non-invasive tests. Lastly, we provide key research questions to be studied in the coming years.

Palabras clave:

MASH NIT míméticos de incretina obesidad pediátrica estratificación de riesgos

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