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Caracterización físico-química de las microemulsiones basadas en líquidos iónicos de superficie activa para mejorar
Mina Tanigawa1, Chew Ben Kiat1, Yukihiro Ono2
1Division of Applied Chemistry, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Chemical & pharmaceutical bulletin
|February 23, 2026
Resumen
Este estudio desarrolló nuevas microemulsiones utilizando disolventes eutecticos profundos y líquidos iónicos activos superficialmente para mejorar la administración de rutina transdérmica. La permeabilidad cutánea de la rutina aumentó significativamente con formulaciones específicas de microemulsión.
Área de la Ciencia:
- Ciencia de los materiales Ciencia de los materiales.
- Ciencias Farmacéuticas Ciencias Farmacéuticas
- Ingeniería Química Ingeniería Química.
Sus antecedentes:
- La administración transdérmica eficiente de fármacos sigue siendo un desafío.
- La rutina, un flavonoide, tiene un potencial terapéutico pero poca penetración en la piel.
- Las microemulsiones (ME) ofrecen un vehículo prometedor para la administración de fármacos.
Objetivo del estudio:
- Desarrollar un nuevo sistema de microemulsión (ME) para la administración transdérmica eficiente de rutin.
- Investigar el papel de los disolventes eutecticos profundos (DES) y los líquidos iónicos superficiales activos (SAIL) en la formulación de ME.
- Evaluar las características estructurales y la permeabilidad cutánea de las EM desarrolladas.
Principales métodos:
- Formulación de EM utilizando cloruro de colina / polietilenglicol (PEG) 200 como DES y bromuros de 1-alquilo-3-metillimidazolio (Cn mimBr) como SAILs.
- Caracterización estructural utilizando dispersión de rayos X de ángulo pequeño (SAXS) y microscopía electrónica de transmisión (TEM).
- Evaluación in vitro de la permeabilidad cutánea de la rutina a través de MEs convencionales de agua en aceite (W/O) y MEs basados en SAIL.
Principales resultados:
- Las EM con C10 mimBr y C12 mimBr exhibieron estructuras cilíndricas, mientras que C16 mimBr formó estructuras esféricas.
- Las EM basadas en SAIL demostraron una permeabilidad cutánea significativamente mejorada de la rutina (aprox. 6,8 veces más alto) en comparación con las MME W/O convencionales.
- La elección de la longitud de la cadena de alquilo en SAILs influyó en la estructura de ME y la permeabilidad de la rutina.
Conclusiones:
- Las microemulsiones a base de SAIL son portadores efectivos para mejorar la administración de rutina transdérmica.
- La morfología estructural de MEs, dictada por SAILs, juega un papel crucial en la permeación de drogas.
- Esta estrategia de formulación es prometedora para el desarrollo de sistemas avanzados de administración de fármacos transdérmicos.
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