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Updated: Feb 25, 2026
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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
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Efecto de la terapia de reemplazo hormonal en el hígado y los resultados cardiometabólicos en el MASLD
Alex E Henney1,2,3, Jo Wilson1, David R Riley1,2,3
1Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.
Resumen
La terapia de reemplazo hormonal (TRH) puede reducir los riesgos para las mujeres con enfermedad hepática esteática asociada a disfunción metabólica (MASLD). Este estudio encontró que la TRH redujo los principales riesgos de enfermedad hepática y cardiometabólica durante cinco años.
Área de la Ciencia:
- Hepatología y Endocrinología.
- Salud de la Mujer Salud de la Mujer.
- Investigación de Enfermedades Metabólicas.
Sus antecedentes:
- La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD, por sus siglas en inglés) es una condición hepática prevalente en todo el mundo.
- La menopausia exacerba la deposición de grasa hepática, aumentando los riesgos de enfermedades hepáticas y cardiovasculares.
- La terapia de reemplazo hormonal (TRH) muestra potencial en estudios preclínicos para mitigar estos riesgos.
Objetivo del estudio:
- Investigar la asociación entre la TRH y el riesgo de resultados hepáticos adversos importantes (MALO) y enfermedades cardiometabólicas en mujeres peri-menopáusicas con MASLD.
- Para comparar los resultados en mujeres que inician TRH frente a controles no tratados.
Principales métodos:
- Estudio de cohorte retrospectivo utilizando la red de investigación federada global TriNetX.
- Se incluyeron mujeres peri-menopáusicas (40-65 años) con MASLD preexistente y al menos un rasgo del síndrome metabólico.
- 1: 1 propensión puntuación de coincidencia de propensión comparó a los usuarios de TRH con controles, analizando los resultados durante 5 años.
Principales resultados:
- La TRH se asoció con un riesgo significativamente reducido de MALO, incluida la ascitis, la peritonitis bacteriana espontánea y la cirrosis hepática.
- HRT también redujo el riesgo de diabetes tipo 2 (T2D) y eventos cardiovasculares adversos importantes (MACE).
- No se observó un aumento en el riesgo de cáncer de mama o tromboembolismo venoso (TEV); se observó una reducción en el riesgo de cáncer de endometrio.
Conclusiones:
- La TRH para los síntomas perimenopáusicos en mujeres con MASLD está relacionada con un menor riesgo a 5 años de enfermedades hepáticas y cardiometabólicas importantes.
- Los hallazgos apoyan una mayor investigación a través de ensayos clínicos para confirmar los efectos protectores de la TRH.
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