Video Experimental Relacionado

Updated: Feb 25, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

PCMTD1-127aa suprime la progresión del osteosarcoma uniéndose competitivamente a USP10 para promover la degradación

Anan Li^1,2,3, Shijiang Wang^1,2,3, Fan Li⁴

¹Department of Orthopedic Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, P.R. China.

|February 24, 2026

Abstract:

Osteosarcoma (OS) is a highly malignant tumor prone to distant metastasis and is associated with a poor prognosis. To date, therapeutic outcomes for this disease remain unsatisfactory. In this study, we found that circPCMTD1 encodes a 127-amino acid protein, termed PCMTD1-127aa in OS. The expression of PCMTD1-127aa was significantly lower in OS tissues than in normal paratumoral tissues. Clinical data analysis revealed that low expression of PCMTD1-127aa was associated with poor OS prognosis. Functionally, overexpression of PCMTD1-127aa not only inhibited the proliferation and invasion of osteosarcoma cells but also suppressed glycolysis in these cells. Mechanistically, PCMTD1-127aa competitively bound to the F1 (1-100) domain of USP10, thereby counteracting the USP10-mediated deubiquitination of c-MYC and subsequently promoting c-MYC degradation. We further identified that amino acid 148 of c-MYC plays a critical role in ubiquitination-mediated degradation. Our findings reveal the PCMTD1-127aa/USP10/c-MYC axis may be a promising therapeutic target for OS.

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Biología Cáncer

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