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SERAPHIM 2.0: una caja de herramientas extendida para estudiar movimientos filogenéticamente informados

Simon Dellicour^1,2,3, Nuno R Faria^4,5, Rebecca Rose⁶

¹Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles (ULB), Brussels, Belgium.

Bioinformatics (Oxford, England)

|February 24, 2026

Resumen

El paquete R actualizado "seraphim" mejora el análisis filogeográfico para la evolución de patógenos. Ofrece nuevas herramientas para visualizar la dispersión, estimar métricas de movimiento y probar el impacto ambiental en la propagación de patógenos.

Palabras clave:

filogeografía epidemiología molecular evolución de patógenos análisis computacional bioinformática

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Área de la Ciencia:

Biología Computacional
Epidemiología Molecular
Bioinformática

Sus antecedentes:

Las reconstrucciones filogeográficas espacialmente explícitas son cruciales para comprender la evolución de los patógenos.
La inferencia filogeográfica continua ayuda a reconstruir la historia de la dispersión de patógenos y la dinámica espaciotemporal.

Objetivo del estudio:

Presentar la segunda versión del paquete R "seraphim".
Proporcionar una caja de herramientas mejorada para procesar y analizar reconstrucciones filogeográficas espacialmente explícitas.

Principales métodos:

El paquete "seraphim" ofrece funciones para visualizar inferencias filogeográficas.
Incluye la estimación de métricas de dispersión de linajes y simuladores filogeográficos.
Implementa pruebas de hipótesis para factores ambientales que influyen en la velocidad, ubicación y frecuencia de la dispersión.

Principales resultados:

El paquete facilita el análisis integral de los patrones de dispersión de patógenos.
Permite la investigación detallada de los impulsores de la propagación de patógenos.

Conclusiones:

El paquete R "seraphim" es un recurso valioso para la epidemiología molecular.
La versión 2 amplía las capacidades para analizar la dinámica espaciotemporal de los patógenos y las influencias ambientales.