Video Experimental Relacionado
Updated: Feb 26, 2026
A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
Published on: April 21, 2023
Evaluación de parámetros derivados de PET/CT con [68Ga]Ga-FAPI en nódulos tiroideos con énfasis en citología
Merve Okuyan1, Umut Elboga2, Mehmet Bastemir3
1Rize, Recep Tayyip Erdogan University, Training and Research Hospital, Department of Nuclear Medicine, Rize, /TURKEY.
Objectives:
To evaluate the diagnostic performance of [68Ga]Ga-FAPI PET/CT-derived metabolic parameters in thyroid nodules and their association with cytological risk stratification, with particular emphasis on indeterminate nodules.
Methods:
Forty patients with 53 thyroid nodules who underwent [68Ga]Ga-FAPI PET/CT were prospectively analyzed. Maximum standardized uptake value and tumor-to-background ratio were calculated for each nodule. Ultrasound-based malignancy classification and Bethesda cytology categories were recorded. Comparisons between benign and malignant nodules were performed in the overall cohort (Bethesda I-VI) and within the Bethesda III-IV subgroup. Multivariable logistic regression was used to identify independent predictors of malignancy. Diagnostic performance was assessed using receiver operating characteristic analysis.
Results:
In the overall cohort, SUVmax and TBR were significantly higher in malignant nodules than in benign nodules (p < 0.01). In multivariable analysis, TBR showed a stronger independent association with malignancy, whereas USG-BM was not independently predictive. Within the Bethesda III-IV subgroup, SUVmax and TBR did not differ significantly in univariable analyses; however, TBR demonstrated a borderline independent association with malignancy in multivariable analysis (p = 0.058). SUVmax and TBR values were significantly higher in Bethesda V-VI nodules compared with Bethesda III-IV nodules (both p < 0.001). ROC analysis demonstrated good discriminative performance for both parameters, with TBR yielding a higher area under the curve and high negative predictive values.
Conclusion:
[68Ga]Ga-FAPI PET/CT-derived metabolic parameters, particularly TBR, show promising diagnostic performance for thyroid nodule characterization. High negative predictive values suggest a potential complementary role for excluding malignancy, especially in indeterminate nodules. Further multicenter studies are warranted.
Advances In Knowledge:
[68Ga]Ga-FAPI PET/CT-derived metabolic parameters were higher in malignant thyroid nodules compared with benign lesions. These findings suggest that FAPI PET/CT may provide complementary functional information in nodules with indeterminate cytology.
