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Gestión de ejecuciones de flujos de trabajo con WESkit

Valentin Schneider-Lunitz¹, Philip R Kensche², Landfried Kraatz¹

¹Center of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10117, Germany Berlin.

Bioinformatics (Oxford, England)

|February 24, 2026

Abstracto

Summary:

In biomedical research, managing computational workflows across numerous projects-with varying parameters, tools, and environments-creates major challenges in scalability, reproducibility, and collaboration. Here we present WESkit, an implementation of the Global Alliance for Genomics and Health (GA4GH) Workflow Execution Service (WES) interface, designed to streamline the execution, monitoring, and documentation of data processing workflows. It addresses the complexities involved in managing numerous executions with varying parameters across diverse research projects. Supporting both Snakemake and Nextflow, the system enables consistent automation and centralized monitoring, which benefits research groups aiming for long-term reproducibility and scalable collaboration. Its suitability for larger teams and service units is further enhanced by seamless integration into cloud environments, contributing to the GA4GH cloud framework.

Availability And Implementation:

The software WESkit is available under MIT license at the GitLab repository (https://gitlab.com/one-touch-pipeline/weskit).The WESkit main repository is archived at Software Heritage (https://archive.softwareheritage.org/browse/origin/directory/? origin_url=https://gitlab.com/one-touch-pipeline/weskit/api.git) and can be found using "one-touch-pipeline/weskit" term in the search section.

Supplementary Information:

Supplementary data are available at Bioinformatics online.

Palabras clave:

WESkit GA4GH WES flujo de trabajo investigación biomédica escalabilidad reproducibilidad bioinformática biología computacional genómica

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