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Análisis bibliométrico de la patogénesis de la enfermedad de Parkinson

Yuan Feng¹, Kaixiao Wang², Xulong Guo¹

¹Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou, Guangdong 510515, China.

Pathology, research and practice

|February 24, 2026

Resumen

La investigación sobre la patogénesis de la enfermedad de Parkinson se está expandiendo rápidamente y revela nuevas tendencias. Las áreas clave incluyen el eje intestino-cerebro y la ferroptosis, lo que cambia el enfoque hacia mecanismos sistémicos en lugar de vías aisladas.

Área de la Ciencia:

Neurociencia
Investigación Biomédica
Genética

Sus antecedentes:

La investigación sobre la patogénesis de la enfermedad de Parkinson (EP) ha experimentado un crecimiento significativo de 2015 a 2024.
Este estudio ofrece una visión general completa de los avances y tendencias para los investigadores.

Objetivo del estudio:

Analizar y visualizar las tendencias e puntos críticos de la investigación mundial sobre la patogénesis de la enfermedad de Parkinson.
Proporcionar información sobre los mecanismos emergentes y las direcciones futuras de la investigación.

Principales métodos:

Análisis bibliométrico de 3140 artículos de la Colección Central de Web of Science (2015-2024).
Se utilizaron CiteSpace y VOSviewer para la visualización y el análisis de datos.
Análisis de coocurrencia de palabras clave para identificar puntos críticos de investigación.

Principales resultados:

Se observa una tendencia ascendente significativa en las publicaciones desde 2015, con China, EE. UU. e Italia como principales contribuyentes.
Los puntos críticos clave de la investigación incluyen la agregación de alfa-sinucleína, la disfunción mitocondrial, la neuroinflamación y el sistema autofagia-lisosoma.
Las tendencias emergentes destacan el eje intestino-cerebro y la ferroptosis, lo que indica un cambio hacia mecanismos sistémicos.

Conclusiones:

La investigación sobre la patogénesis de la enfermedad de Parkinson está ganando una atención sustancial a nivel mundial.
El análisis bibliométrico revela tendencias y puntos críticos clave, y ofrece perspectivas valiosas para futuros estudios sobre los mecanismos de la EP.

Palabras clave:

Análisis bibliométrico Interacciones neuroinmunes Enfermedad de Parkinson Patogénesis Estrategias terapéuticas

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