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Curcumina y Curcuminoides: Actividades Biológicas y Estudios Clínicos
Vincenzo Aiello1, Domenico Iacopetta1, Alessia Catalano2
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Current medicinal chemistry
|February 24, 2026
Resumen
La curcumina, derivada de la cúrcuma, muestra promesa como agente antimicrobiano, antiinflamatorio y antioxidante. Las nanoformulaciones mejoran su eficacia para diversas enfermedades, complementando potencialmente las terapias tradicionales.
Área de la Ciencia:
- Farmacología y Química de Productos Naturales
- Química Medicinal
- Biotecnología
Sus antecedentes:
- Curcuma longa L. (cúrcuma) produce curcuminoides, incluida la curcumina, conocida por sus actividades biológicas.
- La eficacia in vitro de la curcumina es limitada in vivo debido a su pobre biodisponibilidad.
- Se desarrollan nanoformulaciones para mejorar la biodisponibilidad y el potencial terapéutico de la curcumina.
Objetivo del estudio:
- Revisar los efectos antimicrobianos, antiinflamatorios y antioxidantes de la curcumina y sus derivados.
- Explorar el papel de la curcumina en el cáncer, enfermedades crónicas degenerativas y autoinmunes.
- Resumir los ensayos clínicos sobre nanoformulaciones a base de curcumina.
Principales métodos:
- Revisión narrativa de la literatura de PubMed, Web of Science, Scopus y Google Scholar.
- Las palabras clave incluyeron nanocurcumina, nanopartícula de curcumina y nanoformulaciones de curcumina.
- Enfoque en estudios de intervención, ensayos controlados y ensayos controlados aleatorizados.
Principales resultados:
- La curcumina y sus derivados exhiben propiedades antimicrobianas, antiinflamatorias y antioxidantes.
- Se destaca su participación en el cáncer y enfermedades crónicas/autoinmunes.
- Se presentan ensayos clínicos que investigan nanoformulaciones de curcumina.
Conclusiones:
- La curcumina y los curcuminoides poseen efectos biológicos significativos, mejorados por las nanoformulaciones.
- Estos compuestos muestran potencial para aumentar las terapias convencionales para trastornos relacionados con la inflamación y el estrés oxidativo.
Palabras clave:
Cúrcumaactividades biológicascurcuminacurcuminoidejengibremetabolitosnanoformulacionesMás Videos Relacionados
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