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Updated: Feb 26, 2026

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Descubrimiento de fármacos covalentes: progresos contra dianas clave, estrategias emergentes y lecciones aprendidas

Charles P Brown1,2, Alan Armstrong1, David J Mann2

  • 1Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, UK.

British journal of pharmacology
|February 25, 2026
PubMed
Resumen

El descubrimiento de fármacos covalentes está avanzando rápidamente, con más de 75 fármacos aprobados. Esta revisión destaca las dianas clave y las moléculas covalentes exitosas, mostrando su eficacia única.

Palabras clave:
fármacos covalentesdescubrimiento de fármacosinhibición irreversiblemoléculas pequeñasdescubrimiento de fármacos basado en la estructura

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