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C3 y CFD, reguladores pronósticos significativos en la progresión de GIST, identificados mediante cribado sistemático

Yuxuan Ma1,2, Xin Liu1,2, Yuhao Wang1,2

  • 1Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Molecular and cellular biology
|February 25, 2026
PubMed
Resumen

Los genes clave C3 y el factor del complemento D (CFD) se identificaron como supresores tumorales cruciales en los tumores del estroma gastrointestinal (GIST). Su regulación decreciente en GIST se correlaciona con la progresión de la enfermedad y la mala supervivencia, ofreciendo nuevas dianas diagnósticas y terapéuticas.

Palabras clave:
C3Tumor del estroma gastrointestinalFactor del complemento DSensibilidad a fármacosInfiltración inmuneVía metabólicaMicroambiente tumoral

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