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Estrategias de formulación para la liberación de fármacos específica para el colon: de los sistemas convencionales a
Ashish Sriram Mishra1, Bhavna Ghosh2, Sivakumar Ponnurengam Malliappan3
1Department of Pharmaceutical Quality Assurance, SRM College of Pharmacy, SRM Institute of Science and Technology Kattankulathur Chengalpattu 603203 Tamil Nadu India manimarv@srmist.edu.in.
RSC advances
|February 25, 2026
Resumen
Los sistemas de administración de fármacos dirigidos al colon (CDDS) tienen como objetivo mejorar el tratamiento de los trastornos del colon superando los desafíos de formulación. Las estrategias avanzadas, incluida la nanotecnología, ofrecen soluciones prometedoras para la administración eficaz de fármacos en el colon.
Área de la Ciencia:
- Farmacología
- Ciencia de biomateriales
- Liberación de fármacos
Sus antecedentes:
- Los sistemas de administración de fármacos dirigidos al colon (CDDS) son cruciales para tratar trastornos del colon como EII, SII y cáncer colorrectal.
- La administración dirigida mejora la eficacia, reduce los efectos secundarios y mejora la adherencia del paciente.
- Las barreras fisiológicas (pH, microbios, enzimas, tiempo de tránsito) presentan importantes desafíos de formulación.
Objetivo del estudio:
- Proporcionar una revisión exhaustiva de las estrategias de formulación convencionales y avanzadas para CDDS.
- Discutir críticamente varios enfoques y resaltar las tendencias emergentes.
- Guiar el diseño futuro de formulaciones para una entrega eficiente de fármacos en el colon.
Principales métodos:
- Revisión de la literatura sobre estrategias de formulación de CDDS.
- Discusción de sistemas basados en pH, dependientes del tiempo, activados por microbios, profármacos, controlados por presión y basados en nanotecnología.
- Destacando formulaciones basadas en polisacáridos naturales e híbridos.
Principales resultados:
- Existen múltiples estrategias para CDDS, incluidos sistemas sensibles, profármacos y nanotecnología.
- Los polisacáridos naturales y las formulaciones híbridas representan áreas emergentes.
- La nanotecnología y los biomateriales muestran promesa para superar los desafíos de la entrega.
Conclusiones:
- Las estrategias de formulación avanzadas, en particular la nanotecnología, son clave para superar los desafíos de CDDS.
- Se necesita más investigación para traducir estos sistemas en aplicaciones clínicas.
- Los CDDS mejorados pueden conducir a mejores resultados terapéuticos y adherencia del paciente.
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