Video Experimental Relacionado

Updated: Feb 26, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay

Published on: September 10, 2016

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Alostería entre Regiones Estructurales Distantes Dicta la Selectividad en el Acoplamiento GPCR:Proteína G

Elizaveta Mukhaleva1,2, Edgardo J Sánchez Rivas3, Sergio Branciamore1,2

  • 1Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Monrovia, California 91016, United States.

Biochemistry
|February 25, 2026
PubMed
Resumen

Comprender la selectividad del acoplamiento de la proteína G de los receptores acoplados a proteína G (GPCR-G) es clave. Las interacciones cooperativas dentro del núcleo de la proteína Gα, identificadas mediante aprendizaje automático y simulaciones, pueden usarse para diseñar proteínas Gα para vías de señalización específicas.

Palabras clave:
selectividad de acoplamiento GPCR-Gproteína Gαinteracciones alostéricasingeniería de proteínasaprendizaje automáticosimulaciones de dinámica molecular

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