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Updated: Feb 26, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

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Efecto pronóstico de la inflamación sistémica en pacientes sometidos a cirugía de reducción de volumen y

Ahmet Kayahan Tekneci¹, Hasan Yavuz², Gizem Keçeci Özgür³

¹Department of Thoracic Surgery, Ege University Faculty of Medicine, İzmir, Türkiye.

Turk gogus kalp damar cerrahisi dergisi

|February 25, 2026

Abstracto

Background:

To investigate prognostic significance of systemic inflammation-related parameters in patients undergoing cytoreductive surgery and hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma (MPM).

Methods:

Data from 55 patients were analyzed retrospectively. Demographic characteristics, survival outcomes and inflammation-related parameters (neutrophil/lymphocyte ratio [NLR], platelet/lymphocyte ratio [PLR], lymphocyte/monocyte ratio [LMR] and pan-immune inflammation value [PIV]) were evaluated.

Results:

Overall survival (OS) was 61.26±13.03 (3-79) months in patients with low NLR, whereas, it was 23.18±3.53 (1-147) months in patients with high NLR (p=0.012). No statistically significant differences in OS were detected according to LMR, PLR and PIV. In addition, OS was 24.40±4.91 (3-92) months in men and 52.8±10.92 (1-147) months in women (p=0.031).

Conclusion:

In this study, NLR was found to be associated with survival in agreement with the existing literature, thereby distinguishing it from other inflammatory markers as a prognostic factor. In clinical practice, predicting patient prognosis based on pre-treatment NLR may provide a valuable guidance for treatment decision-making.

Palabras clave:

HITHOC Inflamación sistémica cirugía de reducción de volumen mesotelioma pleural pronóstico

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