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Updated: Feb 26, 2026

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Emergencia de un Sistema Nervioso Central: Un Modelo Evolutivo en Dos Pasos Sugerido por Experimentos en Erizos de

Shunsuke Yaguchi¹

¹Shimoda Marine Research Center, University of Tsukuba, Shizuoka 415-0025, Japan, yag@shimoda.tsukuba.ac.jp.

Zoological science

|February 25, 2026

Resumen

La evolución del sistema nervioso centralizado (SNC) en bilaterales implicó un proceso en dos pasos. La señalización Wnt estableció un neuroectodermo anterior, mientras que la señalización TGF-β restringió la neurogénesis, permitiendo la centralización de las neuronas.

Conclusiones:

Un modelo de dos pasos que involucra el patrón anterior mediado por Wnt y la restricción neural mediada por TGF-β explica la emergencia del SNC.
Los embriones de erizo de mar proporcionan un sistema modelo para estudiar la evolución del SNC.
Los mecanismos antiguos de patrón axial fueron cooptados para la evolución de un sistema nervioso centralizado.

Palabras clave:

BMP Nodal señalización Wnt evolución del sistema nervioso neuroectodermo ectodermo no neural erizo de mar

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