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Conservative Site-specific Recombination and Phase Variation

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

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Video Experimental Relacionado

Updated: Feb 27, 2026

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

Published on: January 3, 2015

Predictor PON-Del para deleciones de proteínas que retienen secuencias

Haoyang Zhang¹, Muhammad Kabir¹, Mauno Vihinen¹

¹Department of Experimental Medical Science, Lund University, Lund, Sweden.

PLoS computational biology

|February 25, 2026

Resumen

No abstract available in PubMed .

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