Video Experimental Relacionado

Updated: Feb 28, 2026

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis

Published on: May 23, 2025

Fibrosis pulmonar en caballos asociada con intoxicación espontánea por Crotalaria juncea

Andrezza C Andrade¹, Silvio M C Fonseca¹, Givaldo B Silva Filho¹

¹Laboratório de Diagnóstico Animal, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros s/n, Recife, PE 52171-900, Brazil.

Toxicon : official journal of the International Society on Toxinology

|February 25, 2026

Abstract:

We report an outbreak of Crotalaria juncea intoxication in horses exhibiting progressive weight loss and respiratory distress in northeastern Brazil. Necropsy revealed firm, non-collapsed lungs with extensive interstitial fibrosis, bronchiolar epithelial hyperplasia with club cells proliferation, and marked pulmonary arterial remodeling. Hepatic lesions consisted primarily of centrilobular necrosis, probably resulting from hypoxic injury related to anemia and prolonged agonic death. Pasture inspection identified significant invasion by shrubs of C. juncea in various phenological stages.

Palabras clave:

Crotalaria Équidos neumopatía alcaloides de pirrolizidina

Más Videos Relacionados

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Videos de Conceptos Relacionados

Other Pulmonary Disorders

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

Pulmonary Cycle: Exhalation

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...