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Updated: Feb 27, 2026

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Momento de la diferenciación dependiente del tiempo de la axonotaxis y la especificación de subtipos en las células

Lena Iwai¹, Tatsumi Hirata^1,2

¹Brain Function Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan.

Frontiers in neuroscience

|February 26, 2026

Abstract:

Subtypes of retinal ganglion cells (RGCs) in the mouse retina are each tuned to particular visual features and contribute to parallel visual processing in the brain. We addressed how RGCs are specified into distinct and diverse subtypes based on their differentiation timing. We used a neurogenic tagging mouse line, Neurod1^CreER (D1B), in which tamoxifen-inducible CreER was driven by a putative Neurod1 enhancer. Timed tamoxifen injection in this mouse line induced CreER-loxP recombination in neurons that shared the same differentiation timing. This analysis revealed that RGC axon projections to the lateral geniculate nucleus and medial terminal nucleus were segregated depending on the stage of tamoxifen injection. We further characterized the properties of these neurogenically tagged RGCs based on their molecular markers and morphological features. Our study extends the concept that differentiation timing is linked to the specification of RGC subtypes.

Palabras clave:

CreER Neurod1 núcleo geniculado lateral núcleo terminal medial ratón de etiquetado neurogénico célula ganglionar de la retina especificación de subtipos sistema visual

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