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Updated: Feb 27, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Nuevas saponinas tipo oleanano de las hojas de Derris trifoliata

Bui Thi Mai Anh¹, Nguyen Thi Mai¹, Phan Van Kiem²

¹Basic Science Department, University of Transport and Communications 3 Cau Giay, Lang Hanoi Vietnam.

|February 26, 2026

Abstract:

Phytochemical investigation of the polar fraction of the leaves of Derris trifoliata led to the isolation of five new oleanane-type saponins, named derristrifosides A-E (1-5). Their chemical structures were elucidated through comprehensive analyses of HR-ESI-MS and one-dimensional and two-dimensional NMR spectra. These new saponins possess a cantoniensistriol-type sapogenin framework, which is rarely found in vascular plants. Compounds 1-5 exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells and weak antiproliferative activity against SK-LU-1 and Hep-G2 human cancer cell lines.

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