Video Experimental Relacionado

Updated: Feb 27, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

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Published on: June 20, 2014

Oxidación aeróbica de N,N-dimetilanilinas a N-formilanilinas catalizada por tionxantona bajo luz visible

Piotr Szcześniak¹

¹Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland. piotr.szczesniak@icho.edu.pl.

Organic & biomolecular chemistry

|February 26, 2026

Abstract:

A mild and efficient photo-induced method for the direct oxidation of N,N-dimethylanilines using inexpensive, commercially available thioxanthone as a photocatalyst is reported. The reaction proceeds under ambient conditions, in the presence of oxygen and visible light. The resulting formamides can be directly converted into N-methylalanines via a one-pot deformylation process, offering a practical and sustainable strategy for the demethylation of N,N-dimethylanilines. The methodology is operationally simple, scalable, and compatible with structurally diverse substrates. Its synthetic utility was further demonstrated through late-stage functionalization of value added molecules, including Padimate O, Thioflavin T, Mifepristone and Tropinone.

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