Video Experimental Relacionado

Updated: Feb 28, 2026

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
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Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Published on: February 28, 2016

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Degradación del ARNm de alfa-sinucleína/SNCA por RNautofagia

Chihana Kabuta1, Fumihiko Hakuno2, Naoyuki Kataoka2

  • 1Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan; Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Neurochemistry international
|February 26, 2026
PubMed
Resumen

La RNautofagia mediada por SIDT2 degrada el ARNm de alfa-sinucleína a través de una región rica en guanina en su región no traducida 5' (5' UTR). Esta vía influye en la renovación del ARNm de alfa-sinucleína y puede ofrecer información sobre las enfermedades de los cuerpos de Lewy.

Palabras clave:
AutofagiaDemencia con cuerpos de LewyRegión rica en guaninaLisosomasTrastorno neurodegenerativoEnfermedad de Parkinson

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