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Updated: Feb 28, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

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Nanotransportador multifuncional con respuesta al pH para la administración dirigida de azitromicina y la modulación

Siran Wang¹, Lu Yuan², Chang Gao³

¹Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China; University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, 9713AV, Groningen, the Netherlands; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 300071, Tianjin, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, Zhejiang, China.

Acta biomaterialia

|February 26, 2026

Resumen

Este estudio presenta micelas con respuesta al pH que administran azitromicina a biopelículas bacterianas, mejorando su erradicación. Las micelas también se unen a patrones moleculares asociados a patógenos, reduciendo la inflamación y mejorando la supervivencia en modelos de sepsis.

Palabras clave:

peritonitis aguda antiinflamatorio antibacteriano resistencia a los antibióticos micelas nanomedicina

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