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Updated: Feb 28, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Correlatos sinápticos de la tolerancia a las benzodiazepinas

Alexandre Piot1, Jasmina N Jovanovic2

  • 1UCL School of Pharmacy, University College London, London, WC1N 1AX, UK.

Molecular psychiatry
|February 26, 2026
PubMed
Resumen

La tolerancia a las benzodiazepinas se debe a cambios en los circuitos cerebrales, lo que afecta la eficacia y requiere un aumento de la dosis. Comprender estas neuroadaptaciones es clave para el desarrollo de medicamentos más seguros y la mejora de los resultados de los pacientes.

Palabras clave:
tolerancia a las benzodiazepinasneuroadaptacióncambios sinápticosreceptores GABAdesarrollo de fármacos

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