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Updated: Feb 28, 2026
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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
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p63 y p73 regulan programas transcripcionales convergentes y específicos de factores en el carcinoma de células
bioRxiv : the preprint server for biology
|February 27, 2026
Resumen
TP63 (p63) y su homólogo TP73 (p73) cooperan en la tumorigénesis del carcinoma de células escamosas (SCC) co-regulando la expresión génica a través de potenciadores compartidos. Esta coordinación impulsa la proliferación y el mantenimiento del tumor, con roles distintos para cada factor.
Sus antecedentes:
- La regulación transcripcional aberrante es una característica distintiva del carcinoma de células escamosas (SCC).
- Los roles específicos de TP63 (p63) y su homólogo TP73 (p73) en la patogénesis del SCC no se comprenden completamente, a pesar de la amplificación de p63 en el SCC.
- Es crucial comprender cómo estos factores de transcripción de linaje coordinan los programas oncogénicos.
Conclusiones:
- p63 y p73 funcionan colaborativamente en el SCC, utilizando elementos potenciadores compartidos para impulsar programas transcripcionales oncogénicos.
- Esta asociación implica tanto regulación cooperativa como específica del factor, impactando la proliferación central y vías celulares distintas.
- El eje p63/p73-Anf regulina representa un nodo crítico que vincula la regulación de la cromatina con la señalización y el mantenimiento del SCC.
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