Video Experimental Relacionado

Updated: Feb 28, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

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Supresión del crecimiento de células cancerosas y la tumorigénesis mediante la focalización de tRNA-Arg-TCT-4-1

Esteban A Orellana, Isobel E Bowles, Xin Yang

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    Resumen

    Este estudio revela que los niveles elevados de tRNA-Arg-TCT-4-1 se correlacionan con un mal pronóstico del cáncer. La inhibición de este ARN de transferencia (tRNA) específico con un oligonucleótido antisentido (ASO) suprimió el crecimiento tumoral y mejoró la supervivencia en modelos preclínicos.

    Palabras clave:
    ARN de transferenciatRNA-Arg-TCT-4-1cánceroligonucleótido antisentidocrecimiento tumoralterapia contra el cáncer

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