Video Experimental Relacionado

Updated: Mar 1, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Reactivador de p53 "pionero" muestra prueba de concepto en ensayo de Fase I

Cancer discovery

|February 27, 2026

Abstract:

Findings from a phase I study show that the p53 reactivator rezatapopt is safe and can elicit responses in patients with a range of solid tumors containing the Y220C mutation. Although the drug was ineffective in tumors with KRAS mutations, and whether the strategy can be applied to more common missense mutations remains unclear, the findings offer proof of concept for p53 reactivation.

Palabras clave:

oncología biología molecular farmacología p53 rezatapopt ensayo clínico tumores sólidos mutación Y220C

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